Chemotherapy is one of the effective means to treat tumors, especially for advanced tumors, chemotherapy is an effective treatment to improve the condition, improve the quality of survival and prolong the survival period. However, chemotherapy drugs are highly toxic and irritating, and drug extravasation often causes serious consequences. First, the treatment of drug extravasation: chemotherapy drug extravasation can cause local pain, local tissue swelling and ulcer necrosis, or the formation of local hard nodes. The general principles of treatment for extravasation of intravenous drug infusion are: ① stop infusion; ② elevate the limb; ③ keep the needle and pump back the extravasated drug; ④ inject 5-10ml saline to dilute the exuded drug; ⑤ local antidote; ⑥ local topical steroid hormone; ⑦ 2% procaine local seal; ⑧ cold compress; ⑨ local topical Chinese medicine or magnesium sulfate, or topical thin potato slices or cucumber slices. Second, the treatment of phlebitis formation: first there is drug extravasation, then there is a vein hardening in the form of strips of change, local skin pigmentation, the powerful local limb numbness swelling pain. Emphasis on prevention, choose a good intravenous infusion, or choose a deep vein placement to infuse chemotherapy drugs, can eliminate such phenomena. In addition, the drug should be diluted to a certain concentration, and the speed should be adjusted when infusing. Therapeutic measures: local hot compresses and topical application of Xylactol cream help to reduce symptoms and recovery.