Key points of sodium replacement therapy in TURP syndrome

    Current options for the treatment of dilutional hyponatremia include hypertonic salt solutions, medullary diuretics, and a number of other symptomatic medications. Great care must be taken in the application of hypertonic salt solutions; too slow or too rapid correction of blood sodium can lead to serious neurological adverse effects, such as myelin formation disorder syndrome of brain cells. Excessive use of strong and effective diuretics such as furosemide can lead to loss of sodium and other essential electrolytes, which in turn can make hyponatremia even worse. To treat such complications, first of all, strong urination and sodium supplementation, strong urination pay attention to the dose, too much can lead to blood volume deficiency, pay attention to blood electrolytes, prevent hypokalemia, the amount of sodium supplementation required = (blood sodium normal value a measured blood sodium value) × 52% × body mass (kg). The method of rapid sodium supplementation: 10% NaCl 30 ml + 0.9% NaCl 100 ml. key points of sodium supplementation: ① avoid rapid, high concentration intravenous sodium supplementation; ② in the acute phase of hyponatremia, sodium ion supplementation at a rate of 1 to 2 mmol/L per hour can relieve symptoms; ③ the increase in plasma osmolality within 24 h should not exceed 12 mmol/L; ④ dynamic monitoring of electrolytes and urine output; ⑤ generally give 1/3 of the blood electrolytes first. ⑤ generally give 1/3 or 1/2 of the amount first, so that the osmolarity of extracellular fluid increases, intracellular water is transferred to the extracellular, and cell function is restored, observe for 30 min, and input the remaining hypertonic saline as appropriate according to the mental and psychiatric status, blood pressure, cardiopulmonary function and blood sodium level; ⑥ sodium supplementation can maintain the blood sodium level at 130 mmnol/L. Avoid rapid sodium supplementation leading to impaired brain cell myelin formation syndrome. Liang Yujie, Department of Obstetrics and Gynecology, Yueqing People’s Hospital