Acute exacerbation of chronic bronchitis may be manifested by coughing, coughing up phlegm or worsening of chest tightness, which need to be selected according to the different manifestations of the appropriate drugs, such as cough, phlegm or asthma treatment, such as the combination of bacterial infections, but also the use of antibiotic treatment. 1. Cough, cough and phlegm as the main symptoms: acute exacerbation of chronic bronchitis, if cough, cough and phlegm as the main symptoms, you need to use cough, phlegm drugs, such as Ambroxol dispersible tablets, eucalyptus-pin enteric soft capsule. 2. Chest tightness and wheezing as the main symptom: if the main manifestation of acute attack of chronic bronchitis is chest tightness and wheezing, you can take theophylline extended-release tablets and other asthma medications, such as chest tightness, may also need to be hospitalized to take oxygen inhalation and other asthma treatment measures. 3. Combined bacterial infection: If acute exacerbation of chronic bronchitis is characterized by bacterial infection, for example, blood routine suggests that leukocytes are obviously elevated or neutrophils are obviously elevated, it may be necessary to use antibiotics such as levofloxacin, moxifloxacin, and so on, empirical antibiotics are used at the same time, perfect sputum culture and other pathogenicity testing and drug sensitivity, according to the results of the return to adjust the antibiotic treatment. In summary, chronic bronchial acute exacerbation, we need to improve the relevant laboratory tests in a timely manner, combined with the specific conditions of the standardized treatment in accordance with the doctor’s instructions.