There is no best treatment for primary biliary cirrhosis. The treatment methods are different in the early and late stages of the disease, which generally include drug treatment and surgery. Ursodeoxycholic acid is more effective in the early stage of primary biliary cirrhosis. The drug can slow down the progression of the disease by increasing the secretion of bile acids and protecting liver cells and bile duct cells. Ursodeoxycholic acid, as the drug of choice for primary biliary cirrhosis, may improve the condition of most patients after 6 to 9 months. The advanced stage of primary biliary cirrhosis or the combination of other serious complications requires surgical treatment, and the survival rate of patients is improved by liver transplantation. In daily life, patients are advised to take a light diet, do more physical exercise and keep an optimistic mood. It is recommended that patients should consult a doctor in time if they have any discomfort, and try to treat the disease at an early stage to avoid adverse consequences.