Primary biliary cirrhosis liver function is normal in the early stage, with the development of the disease, liver function is abnormal gradually, the main lesion is the damage of intrahepatic bile ducts. In the early stage of primary biliary cirrhosis, only the anti-mitochondrial antibody is positive, and there is no other abnormality, the liver function is not abnormal at this time. As the disease progresses, abnormal liver function with cholestatic jaundice as the main alteration occurs. Serum bilirubin is generally moderately elevated, with a predominant increase in direct bilirubin, serum cholesterol may be elevated, and alkaline phosphatase and γ-glutamyltransferase are mostly elevated before the onset of jaundice and other symptoms. If primary biliary cirrhosis is diagnosed, early standardized treatment is recommended to reduce the adverse effects of the disease.