Case: Wang, female, 53 years old, started to have right-sided hypochondriacal pain and discomfort, weakness, and itchy skin in January, and went to the local community hospital. The doctor told him to take more rest and eat a light diet, and prescribed some liver-protective drugs (specific drugs are not available). One week after taking the medication, the weakness, right hypochondriacal distension and skin itching did not improve significantly, and then he went to the hepatology clinic. After two weeks of taking the medication, the above-mentioned symptoms were reduced and TB and AKP decreased. After three months of continued treatment with Eusebio combined with Chinese herbal medicine, the symptoms of distension and itching in the rib cage disappeared, and the fatigue was slight. Primary biliary cirrhosis (PBC) is an autoimmune disease that occurs in middle-aged and older women, and most of the cases have no clinical symptoms at the time of diagnosis. The prognosis is poor. Therefore, we would like to remind you to perform relevant tests when you find unexplained liver function impairment to identify the cause as much as possible. Although PBC usually progresses slowly, its survival rate is lower than that of the same sex and age group; at the same time, if left unchecked, it will progress to liver fibrosis, cirrhosis and cirrhosis-related complications, such as common cirrhotic ascites, gastric fundic vein bleeding, and hepatic encephalopathy, which will seriously affect patients’ quality of life and even endanger their lives. common clinical manifestations of PBC include weakness, itchy skin, portal hypertension, osteoporosis, yellow warts on the skin, fat-soluble vitamin deficiency, and recurrent asymptomatic urinary tract infections. In view of this, the following recommendations are given to clinicians and patients for PBC. I. Suggestions for PBC diagnosis 1. If the patient has unexplained elevated AKP (ultrasound shows normal bile duct), it is of great value to perform AMA examination. 2. If AMA is positive (especially M2 type AMA positive), combined with biochemical manifestation of cholestasis and no other causes can explain, the diagnosis of PBC can be made, and histological examination of liver biopsy can help to confirm the diagnosis. 3. Patients with positive AMA and normal AKP should be followed up and liver function tests should be performed annually. 4. Patients with elevated AKP (normal bile ducts on ultrasound) and negative AMA without other explanations should have immunoglobulin measurement or even liver biopsy histology at this time. If AMA is negative or presents weakly positive with low titer or the patient’s biochemistry is dominated by elevated transaminases, liver biopsy is necessary to clarify the diagnosis of PBC or to exclude the diagnosis of PBC. Specific treatment of PBC All patients with abnormal liver function should be treated specifically. So far, there is no report on the application of immunosuppressive therapy to prolong the life span of PBC patients. Ursodeoxycholic acid (UDCA), although it cannot reduce the need for liver transplantation, can improve the overall serum biochemical indexes of cholestasis, delay the time when patients need liver transplantation, and potentially prolong the life span of patients. Happily, in recent years, Chinese medicine has shown better advantages in improving clinical symptoms and protecting liver function in the treatment of PBC, and most patients have obtained more satisfactory clinical results through a comprehensive treatment program. Prevention of daily life 1. Absolutely abstain from alcohol (including beer and rice wine) and drink less of various beverages. 2, daily diet to maintain a constant, low salt, low fat, less sugar, high protein, do not eat spicy, greasy, fried, sticky and hard food, do not overeat, and pay attention to dietary hygiene, to prevent diarrhea. 3, try not to eat food and drugs that damage the liver. 4. Maintain the habit of proper exercise and a good state of mind. Finally, it is cautioned that for those with typical clinical manifestations of PBC, there is no difficulty in diagnosis, but the condition is mostly advanced at this time, so early diagnosis is the key to success or failure of treatment.