Primary biliary cirrhosis is usually not self-healing, and the disease can affect the quality of life to some extent, requiring aggressive treatment to improve the prognosis. Primary biliary cirrhosis is a chronic cholestatic disease caused by chronic progressive non-suppurative inflammation of the small intrahepatic bile ducts. The pathogenesis of the disease is unclear and may result from the interaction of genetic, immune dysfunction, and environmental factors. The disease is usually not self-healing through self-resistance. In most cases, the disease is asymptomatic in the early stages, but as the disease progresses, it can be complicated by osteochondrosis, osteoporosis, fat-soluble vitamin deficiency, and other diseases. Therefore, this disease can affect the quality of life and requires active treatment. Ursodeoxycholic acid is the preferred treatment, which can increase the secretion of bile acids and protect the bile duct cells and hepatocytes. Complications such as osteoporosis can be treated with vitamin D and calcium. Fat-soluble vitamin deficiencies can be treated by supplementing fat-soluble vitamins A, E, D, and so on. It is recommended to seek timely medical treatment, specific treatment methods and medication need to follow the doctor’s instructions, active treatment can improve the prognosis.