Early symptoms of biliary cirrhosis may also include breast swelling and testicular shrinkage. The liver plays an important role in the balance of sex hormones in the body’s blood. As estrogen increases and androgen decreases in the early symptoms of cirrhosis, men can see enlarged and distended breasts and shrunken testicles. For women, sex hormone disorders in cirrhosis, early symptoms of cirrhosis can also cause menstrual disorders, breast shrinkage, and scanty pubic hair. Wasting and darkening of the face, more than 1/3 of patients suffering from chronic hepatitis or cirrhosis have darker and darker skin on the face and around the orbits than before the disease, which is due to the decrease of liver function, resulting in the increase of melanin production. OVERVIEW The disease is an unexplained, chronic progressive cholestatic liver disease that may be autoimmune related. Co-occurrence is associated with intrahepatic cholestasis and prolonged extrahepatic bile duct obstruction. -Service is divided into two types: intrahepatic cholestatic and extrahepatic bile duct obstruction cirrhosis. The combination is mostly caused by intrahepatic small bile ducts disease caused by biliary siltation, which is related to autoimmunity, known as primary biliary cirrhosis, the latter is mostly secondary to extrahepatic bile duct obstruction, so it is called secondary biliary cirrhosis. The main clinical manifestations of biliary cirrhosis are chronic obstructive jaundice and hepatosplenomegaly, and portal hypertension and hepatic failure can also occur in the advanced stage. History and Symptoms This disease often coexists with other immune diseases such as rheumatoid arthritis, dry syndrome, scleroderma, chronic lymphocytic thyroiditis, etc. It is mostly seen in middle-aged women, with insidious onset, slow progression, mild early symptoms, good general condition, no obvious decrease in appetite and weight, and about 10% of the patients may be asymptomatic. For patients with chronic progressive obstructive jaundice of unknown cause, especially those with steatorrhea, we should know in detail the causative factors of the disease and the progress of the disease, whether there are other immune diseases, and pay attention to differentiate from secondary biliary cirrhosis and other causes of liver cirrhosis with jaundice. Clinical manifestations Physical examination reveals yellow staining of skin and sclera, with multiple scratches and flaking. The liver and spleen are enlarged, the surface is still smooth and there is no pressure pain. Lipids, serum bile acids, conjugated bilirubin, AKP and GGT and other microbiliary enzymes are significantly elevated, and transaminases are normal or mildly or moderately elevated. Blood was positive for anti-mitochondrial antibodies and IgM was elevated . Prolonged prothrombin time. Positive urinary bilirubin and normal or decreased urinary biliogen [1]. EXPERIENCIAL FINDINGS Skin and sclera are yellowish, multiple scratches and flaking are seen. Hepatomegaly and splenomegaly Surface is still smooth, no pressure pain. Ancillary tests Lipids, serum bile acids, conjugated bilirubin, microbiliary enzymes such as AKP and GGT are markedly elevated, and transaminase is normal or mildly or moderately elevated. Blood anti-mitochondrial antibody is positive, IgM is elevated, and prothrombin time is prolonged. Urine bilirubin is positive, and urinary bilirubin is normal or decreased. Imaging Ultrasound, ERCP, CT, and PTC for the presence of intra- and extrahepatic bile duct dilatation and diseases causing extrahepatic obstructive jaundice. Prevention Appropriate rest, give high protein, high carbohydrate, high vitamin and low fat diet, fat <40~50g per day is appropriate. Supplement fat-soluble vitamins A, D, E, K. Ursodeoxycholic acid can improve the clinical symptoms and laboratory test indexes if the drug is taken for more than 6 months; corticosteroids such as hydroprednisone can be taken orally. Pay attention to the exacerbation of bone disease and concurrent bacterial infections in patients with advanced disease. Azathioprine and cyclosporine A are effective, but should be used with caution due to nephrotoxicity and myelosuppression. Implementation of the treatment of the disease process should be aware of the side effects of drugs. Liver transplantation may be considered in patients with concomitant hepatic decompensation and/or poor quality of life. Diagnosis is not difficult in patients with typical clinical manifestations, but at this time the disease is mostly advanced, so early diagnosis is the key to the success or failure of treatment. The following lifestyle is helpful for the prevention of this disease: 1. Absolutely prohibit alcohol (including beer and rice wine), drink less of all kinds of beverages, and drink hot tea. 2. 2, daily diet to maintain a constant, low-salt, low-fat, less sugar, high protein for good, do not eat spicy, greasy, fried, sticky and hard food, do not overeat, and to pay attention to dietary hygiene, to prevent diarrhea. 3.Try not to eat foods that damage the liver. 4.Keep the habit of exercise and a good mindset.