In clinical practice, we often encounter patients who are diagnosed with primary biliary cirrhosis and believe that their liver has been cirrhotic, so they are “stressed out” and in a state of fear. Is this really the case? Primary biliary cirrhosis is an autoimmune disease that occurs in middle-aged or older women. The natural history of primary biliary cirrhosis is divided into four stages: the first stage is preclinical: positive serum anti-mitochondrial antibody (AMA), but no significant abnormalities in liver function and other biochemical indicators. The second stage is the asymptomatic stage: the main manifestation is the abnormal biochemical indexes (alkaline phosphatase is the most prominent biochemical abnormality of the disease, and others such as glutamyl transpeptidase, glutamyl transaminase and glutamic acid aminotransferase are elevated), but there are no obvious clinical symptoms. The third stage is the symptomatic stage: the patient develops clinical symptoms such as weakness and itchy skin. The fourth stage is the decompensated stage: Patients develop clinical manifestations such as gastrointestinal bleeding, ascites, hepatic encephalopathy and even jaundice. Primary biliary cirrhosis was named as early as 1851. Initially, the diagnostic method should be insensitive, and patients were basically not diagnosed until the cirrhosis stage. In recent years, with the improvement of diagnosis, most patients are diagnosed at the early stage of the disease, when the liver is not cirrhotic; and with the standard treatment of ursodeoxycholic acid (UDCA) at the early stage, two-thirds of the patients are expected to survive roughly the same as the normal population, and only very few patients will develop cirrhosis. Therefore, early diagnosis and treatment of primary biliary cirrhosis is very important. Women with symptoms of pruritus, malaise, or unexplained increase in alkaline phosphatase and glutamyl transpeptidase should be promptly seen in the hospital. Considering that the name “cirrhosis” in this diagnosis will bring mental burden and work, life and social problems to patients, domestic and foreign experts have jointly published an article suggesting that “primary biliary cirrhosis” be renamed as “Primary biliary cholangitis”, “cirrhosis” hat can be removed!