Q1, axillary odor and axillary hyperhidrosis produced by the anatomical basis and principles? A: The sweat glands in the axilla include: local sweat glands (also known as eccrine sweat glands, small sweat glands) and parietal sweat glands (also known as the sweat glands). The local sweat glands, which are commonly referred to as sweat glands, are located in most of the body’s skin, including the outer lip, nipple, nail bed, inner foreskin, glans, labia minora and clitoris; they are located at the junction of the dermis and subcutaneous tissue, or in the lower 1/3 of the dermis; the glandular cells and myoepithelial cells of the local sweat glands are mainly innervated by unmyelinated cholinergic nerve fibers, and a small number of adrenergic nerve fiber endings can be seen in the secretory part. The sweat is stimulated by heat, exercise, and emotion to secrete large amounts of water-based, sodium- and potassium-containing plasma, which regulates body temperature and water and electrolyte metabolism in the body. If it is hyperactive and secretes too much sweat, it is called “hyperhidrosis”. The acrosomal sweat gland, also known as the sweat gland, is a special gland in the skin that produces special secretions, located in the armpits, areola, around the umbilicus, perineum, around the anus, prepuce, mons pubis and labia minora, etc. It is innervated by cholinergic and adrenergic nerve fibers, and the secretion is a viscous milky fluid, which can be white, yellow, red or black, containing proteins, carbohydrates, lipids, water, iron and chromogens. The secretion is odorless when it is first secreted, and the lipids are decomposed by bacteria to produce unsaturated fatty acids and form a special odor, if it is hyperfunctional and secretes too much sweat, it forms “axillary odor”, commonly known as “fox odor”. Q2: What is the mechanism of Botulinum toxin type A injection for axillary odor and axillary hyperhidrosis? A: Botulinum toxin type A is a neurotoxin that specifically blocks the release of acetylcholine from acetylcholinergic nerve endings, and because the axillary sweat glands are mainly innervated by acetylcholinergic nerve fibers, it can block the secretion of sweat glands and play a corresponding role. Clinical treatment are safe dose, and it is widely used, such as “facial biological wrinkle removal”, “bite muscle injection for face slimming”, “gastrocnemius injection for calf slimming”, etc. Now it is applied to treat “axillary odor” and “axillary hyperhidrosis” because they have the same mechanism of action, and the effect is reliable, non-invasive and worth promoting. Q3: How long does it take to work after injection? How long can one injection last? Is it easy to produce antibodies? A: Generally speaking, the effect will start 3-7 days after injection; the effective time of one injection is 4-6 months, and some studies believe that a larger dose of injection can prolong the effect (non-multicenter study); generally the injection interval is too short, or the injection dose is too small, it will be easier to produce antibodies, but through years of experience of Botulinum toxin type A injection for wrinkle removal and face slimming, some patients who have been injected regularly (once every six months) for 7-8 times still remain sensitive to Botox. If you are really worried and your financial ability allows, you can choose imported BOTOX Type A Botox, which has higher purity and is less likely to produce antibodies. Q4: What is the cost of Botox Type A injection for armpit odor and axillary hyperhidrosis? A: The cost of domestic injections is about $1800 and the cost of imported BOTOX is $3000. Q5: Are there any unsuitable people and side effects for Botulinum toxin type A injections for armpit odor and axillary hyperhidrosis? A: Generally there is no unsuitable group of people, unless they are allergic to this type of toxin protein, so it is best to observe and rest for 15 minutes after injection before leaving the hospital.