Hyperhidrosis refers to a group of diseases characterized by excessive secretion of sweat glands in the hands that are not affected by external temperature, accompanied by sweating in the feet, armpits, and groin. The prevalence of hand sweating in the population is 2.8%, the onset of the disease does not discriminate between men and women, usually occurring in children and adolescents, and the symptoms tend to be obvious at the age of 20-30 years. About 12% of patients have a family history. Although the disease is not harmful to the body, it often affects the life, work and social life because of the sweaty hands, and it also seriously affects the physical and mental health of the patients. 1, etiology and mechanism Hand sweating can be divided into primary and secondary. Clinically, about 95% of patients are primary. Secondary is rare, mostly due to hyperthyroidism, menopausal syndrome, some special parts of the central nervous system, such as hypothalamic tumors, hemorrhage and so on. The exact etiology and mechanism are still unclear. However, it is certain that it is related to sympathetic nerve dysfunction. When the sympathetic nerve is over-excited, the parasympathetic antagonistic constraints are weakened or the mutual regulation mechanism of the two is out of order, it will produce the internal organs to enhance the function and hyperactivity, and the direct outward manifestation of this is the amount of sweating in the hands. 2, the clinical manifestations of the main hand sweating and skin temperature reduction. Hand sweating is divided into three levels: first (mild) palm skin moisture, surface skin temperature does not change; second (moderate) palm skin sweating accompanied by vesicular sweating, can be infiltrated with a layer of handkerchiefs. Skin temperature is 33-35°C; Grade III (severe) Bilateral palm sweating like raindrops, skin temperature is 30-30°C. Those with years of sweaty hands and feet and lowered skin temperature can mostly confirm the diagnosis when combined with symptoms and signs. What needs to be differentiated is the secondary sweating caused by central nervous system diseases such as: hypothalamic tumor, hemorrhage; hyperthyroidism; menopausal syndrome and other diseases. Most of them can be identified by head CT, thyroid function and basal metabolic rate. 3, treatment methods Treatment of hand sweating throughout the treatment methods. Previously, a variety of conservative treatment is not ideal. Thoracic sympathetic ganglion or nerve trunk resection is currently the only effective and long-lasting treatment for hand sweating. The main mechanism of treatment is to remove the thoracic sympathetic ganglion and block the postganglionic fibers from the ganglion to be distributed to the upper limbs along with the spinal nerves to innervate the sweat glands of the skin. Surgical procedure: ① general anesthesia with single or double lumen tubes; ② supine, head-up position; ③ small surgical holes in the axilla, inserting a mirror sheath to connect the external device of the luminal mirror; ④ searching for the thoracic sympathetic ganglion after the lung atrophy. Extend the electric hook, cut off the sympathetic interganglionic bundle, at the same time, electrocauterize the sympathetic ganglion and cut off the sympathetic parasympathetic branch; ⑤ After electrocauterization of the wound to stop the bleeding, suture the incision, and then close the thread and tie the knot after expanding the lungs. Postoperative complications: ① pleural effusion; ② pneumothorax and subcutaneous emphysema; ③ hemorrhage; ④ Horner’s syndrome; ⑤ compensatory hyperhidrosis. Therapeutic effect: Palm sweating disappeared immediately after the operation, and the hands became dry and warm. Palm temperature increased after surgery.