Patient: left breast ductal carcinoma without metastasis recently underwent mock radical surgery ER-a negative PR negative c-erbB-2 positive ++++ already had chemotherapy for 1 time, someone suggested to do targeted therapy, the internet said that targeted therapy must be HER-2 overexpression, is this my case? What kind of drugs should I use? How much does it cost? Huirui, Department of Breast Oncology, Tianjin Cancer Hospital: c-erbB-2 positive ++++ is HER-2 overexpression, you can use Herceptin, the cost is 150,000~300,000. If there is epi-amycin in the chemotherapy regimen, Herceptin can not be used at the same time, that will increase the cardiotoxicity of epi-amycin. Herceptin but to be less efficient, choose carefully.