After the diagnosis of epilepsy is clear, the next step involves medication. For patients with sparse seizures, 1-2 seizures a year and benign prognosis, medication can be withheld. Before medication is administered, the efficacy and adverse effects of the drug need to be weighed to achieve an optimal balance for the best efficacy and the least adverse effects. For students, children, and patients with poor compliance with medication, a long-acting dosage form can be selected and taken once daily or once in the morning and once in the evening, which makes it easier for family members to supervise. Broad-spectrum antiepileptic drugs, such as Depakene, Lamotrigine, Toltea, and Levetiracetam, are preferred for more than one seizure type and for patients or for patients whose seizure type is still unclear. Antiepileptic drugs have certain adverse effects, and it needs to be explained to the patient and family that the occurrence of mental retardation and cognitive decline is not exclusively an adverse effect of antiepileptic drugs. The patient should be informed of the possible adverse reactions, avoid serious adverse reactions, and have timely follow-up. Also strengthen education on compliance with epilepsy treatment and warn patients that the purpose of medication is to control seizures, not to cure the primary disease causing the epilepsy. Anti-epileptic drugs need at least 5-6 drug half-lives to take effect. If seizures still occur within a short period of time after starting medication, do not change to other drugs at will. If the preferred drug does not work well, it is necessary to change to another type of drug. Do not change the dosage form at will during treatment, do not mix drugs from different manufacturers, do not alternate between regular tablets and extended-release agents. When suffering from other diseases, pay attention to whether the combined medications can trigger epilepsy. Avoid stimulation by triggering factors at all times.