SLE is one of the diseases that belong to the group of autoimmune diseases, which occur when the immune system attacks the body’s own tissues and organs. SLE is a chronic disease that causes multi-organ and multi-system damage in connective tissues, such as the skin and mucous membranes, joints, kidneys, nerves, blood system and vascular internal organs, and other multi-organ systems. Signs and symptoms of SLE vary from individual to individual and may involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and hematopoietic system. SLE can cause a wide range of systemic symptoms. These symptoms mainly include extreme fatigue, fever, loss of appetite and weight loss. This is primarily due to the body’s immune response to the sterile inflammatory mediators produced by SLE. The disease can also present with damage to the motor system. The main manifestations are symmetrical joint swelling and pain, and in severe cases, joint dysfunction can occur without causing joint deformity. Skin problems are common in SLE and are typically characterized by a flat red rash across the cheeks and bridge of the nose, called “butterfly erythema” because of its butterfly-like shape. The rash usually does not break out or itch, and usually becomes more pronounced and painful when exposed to sunlight, a condition called sun sensitivity. It is mainly caused by inflammation of the tiny blood vessels in the skin during the active phase of SLE disease, which causes increased vascular permeability and imperceptible oozing of blood. SLE is a typical autoimmune disease that can have both significant local and systemic symptoms. This is mainly due to pathological changes caused by the body’s immune system fighting against the sterile inflammation caused by this disease, i.e. a series of humoral and cellular immune responses.