Skin cancer is a common cancer that occurs in a large proportion of malignant tumors. Traditionally, skin cancer mainly includes squamous cell carcinoma and basal cell carcinoma. Nowadays, all malignant changes of tissues within the skin are considered as skin cancer, including hair sheath cancer – mostly occurring in coarse hair growth areas; cutaneous lymphadenoma – tumors of lymphatic vessels in the dermis; cutaneous hemangioendothelioma – tumors of capillaries in the dermis; malignant melanoma – skin malignant melanoma – malignant transformation of melanocytes; cutaneous augmentation fibrosarcoma – malignant transformation of subdermal fibrous connective tissue, etc. For the treatment of skin cancer, surgery is still the first choice. Since tumor cells in the skin tend to infiltrate and metastasize along the skin lymphatic vessels, the scope of surgery should be much larger than the conventional scope (1cm from the edge of the tumor). The treatment after surgery mostly adopts local electron beam external radiotherapy, while basal cell carcinoma and cutaneous lymphangiectasia are relatively sensitive to chemotherapy, and adjuvant chemotherapy should also be used. Chemotherapy can be combined with systemic chemotherapy and local chemotherapy, and local chemotherapy can be applied with interventional chemotherapy and surface coating. Since the traditional method of direct coating makes it difficult for drugs to penetrate below 5mm of skin, drugs that help penetration should be added. Immunotherapy can also be used for other tumors that are not sensitized by chemotherapy. Passive immunotherapy – applying interferon, interleukin, transfer factor and thymopentin; active immunotherapy – applying tumor vaccine made from autologous tumor and injecting it into the vicinity of lymph node cluster to make self-produced tumor antibody to inhibit tumor growth; cell therapy – extracting self-produced tumor antibody cells and using them in the laboratory. Cell therapy – extracting tumor antibody cells produced by oneself, culturing and amplifying them in the laboratory and then infusing them back into the patient to increase the tumor suppression ability. As with any malignant tumor, early detection and prevention are still of utmost importance. At present, it is believed that malignant changes may occur when skin tissues are subjected to chronic adverse stimuli, such as long-term sunlight, radiation, long-term exposure to chemicals, chronic skin diseases, and long-term repeated breakage of the same area of skin. It should be noted that: to avoid long-term adverse stimulation, for often easy to rub to the skin swelling as soon as possible to remove, timely treatment of skin disease, can not be ignored is the chronic skin ulcers. One of the most common diseases is skin cancer caused by diabetes or varicose veins, vasculitis and other emergency skin ulcers. If it grows on the scalp, cheeks (male), waist (where the belt is tied), palms and soles of the feet, it is better to remove it as soon as possible.