Hepatitis A and E are both intestinal infectious diseases and are transmitted mainly by fecal-oral transmission, which is often referred to as “disease by mouth”. Fecal-oral transmission can occur in a variety of ways. This type of transmission often occurs in places with poor sanitation and crowded housing; in rural areas, it is particularly likely to occur when fecal matter is not managed properly. Water and food transmission are the main modes of transmission for hepatitis A outbreaks and epidemics. Hepatitis A virus can often contaminate various water sources, such as wells, ponds, rivers, tap water and swimming pool water, through sewage and feces, causing hepatitis A epidemics; food transmission is caused by direct contamination of food or contamination by sewage, especially aquatic products, such as clams, oysters, mud arks and crabs, which are highly susceptible to contamination and play an important role in hepatitis A food transmission, such as the hepatitis A epidemic in Shanghai from January to April 1988 (with an incidence of The number of people up to 300,000), is the raw food is contaminated by the hepatitis A virus caused by the ark. Drinking water contamination is the main mode of transmission of hepatitis E outbreak epidemic, it is reported that New Delhi, India, December 1, 1955 to January 20, 1956 hepatitis E pandemic, in 1.7 million people in 97,000 cases, including 29,300 cases of jaundice hepatitis, the epidemiological investigation confirmed that the cause of the epidemic is the water source of the water supply station was seriously contaminated by domestic sewage. Daily life contact is the main mode of transmission for the sporadic onset of hepatitis A and E. Transmission is generally through contaminated hands, utensils, eating utensils, toys, bedding, clothing, etc., either directly or indirectly via the mouth. Hepatitis A is generally not transmitted via blood. When a blood donor is in the latent phase of end-stage viremia, it can occasionally cause post-transfusion hepatitis A, but such cases are relatively rare. Perinatal transmission of hepatitis A does not occur. Pregnant women with hepatitis A do not infect their fetuses, and no teratogenic effects have been observed. To date, there is no evidence that hepatitis E can be transmitted by extraintestinal routes.