Hepatitis E is a contagious disease due to hepatitis E viral infection. Hepatitis E is contracted through the dietary digestive tract, caused by eating water or food contaminated with the hepatitis E virus, and is particularly likely to occur after flooding during the rainy season. Hepatitis E is transmitted by the same fecal-oral route as hepatitis A. The virus enters the body through the mouth and proliferates. The virus enters the body through the mouth to proliferate and multiply, and is then excreted in the stool. Therefore, it is important to eat cooked food and to strictly disinfect the stool of hepatitis E patients. The clinical manifestations of hepatitis E are rapid onset, jaundice, general malaise, nausea and vomiting, fever, pain in the liver, biliary stasis, itchy skin, and hepatomegaly. Hepatitis E examination is done by specific serum pathogenic tests, which are the basis for confirming the diagnosis. It should also be combined with clinical symptoms, liver function tests, epidemiological examinations, etc. The treatment of hepatitis E is reasonable nutrition, proper rest, and the use of appropriate liver-protective drugs. Do not drink alcohol, do not stay up late, do not overexert yourself, and avoid using drugs that damage the liver. Also protect water sources, strengthen fecal management, improve sanitary conditions and facilities, and pay attention to food hygiene. In conclusion, hepatitis E is an infectious disease that requires prevention in addition to treatment. Take comprehensive measures to cut off the transmission route of hepatitis and develop the habit of washing hands before meals and after stools.