The sciatic nerve is the longest nerve in the body and is more susceptible to injury than other nerves, so the incidence of sciatica is high. Sciatica can be caused by many reasons, and only when the cause is clear can targeted treatment be carried out. The causes of sciatica are as follows: 1, mechanical compression: lumbar disc herniation, crestal spine tumors, etc. can compress the sciatic nerve and produce pain. 90% of sciatica is caused by compression factors, most commonly in lumbar disc herniation. 2.Neuritis: lead poisoning, alcoholism, diabetes, vitamin B1 deficiency, and viral infection can all cause sciatica, and lead to sciatica. 3, Involvement pain: perianal disease, hip arthritis and lumbosacral arthritis reflexes cause sciatica. Clinical manifestations of sciatica: Patients usually have lumbago first, but the lumbago is weak and soon develops into severe thigh and calf pain, mostly one-sided lower limb pain. The pain is felt when standing, sitting, walking, stretching the legs, lifting things; the pain increases when coughing, sneezing, and straining to defecate. Multiple treatments for sciatica: Since the course of sciatica is slow and prolonged, it seriously affects the patient’s work and life and must be diagnosed and treated early. First of all, it is necessary to visit a hospital and carry out the correct treatment based on a clear definition of the cause. Nerve block is one of the commonly used treatment methods, such as lumbar major interosseous groove block is safe and effective. Other treatments include: (1) rest, lying flat on a plank bed, keeping the lower back warm and elevating the affected limb; (2) analgesic sedation (specific medication under the guidance of a doctor); (3) vasodilators and vitamins; (4) dehydrating agents; (5) Chinese herbal medicine treatment, acupuncture treatment, physiotherapy, etc.