1, medication on time, not on demand The pain treatment process, many patients are accustomed to their own no pain immediately stop the drug, feel pain when the medication will be taken. But these wrong practices this often postpone the condition and intensify the repeated deterioration of the condition. Timely medication means that pain medication should be given regularly at prescribed intervals instead of taking medication on demand (waiting for patients to take medication only when they are in pain). 2. Early and adequate treatment is more beneficial. Nerves are plastic. Neuropathic pain is caused by the pathological shaping of nerves due to disease, i.e. shaping into a state of central hypersensitivity (central sensitization). The longer the pain is, the more stubborn the nerves are shaped, and the more difficult it is to eliminate the treatment of central sensitization later, so early treatment is needed. Central sensitization is a process of continuous progressive deterioration, including synapses, membrane excitability, molecular signaling, ion channels, etc., that continues to change. The need to select targeted drugs for adequate and full course of treatment to reverse the progression of central sensitization is an important tool for treating chronic pain. And for various reasons leading to recurrent disease, after the formation of long-term sustained changes in the nervous system, it is difficult to reverse, usually need to be taken for life. 3, discontinuation of medication should be based on effective and stable treatment effect 40% of chronic pain is accompanied by neuropathic pain component. And neuropathic pain is a continuous process, the condition may recur, requiring long-term treatment. The first-line drugs for the treatment of neuropathic pain are mostly neurological drugs (such as anticonvulsants, tricyclic antidepressants, etc.), and the dosing and discontinuation of these drugs usually require a gradual approach, especially the premise of discontinuation needs to be based on effective and stable treatment effects and a gradual reduction in dosage to avoid rebound effects. The correct dosage and full course of medication is the key to the mechanistic treatment of neuropathic pain.