Parkinson’s disease is a progressive disease that begins with a distal tremor or strong value in one limb and slowly progresses to the other limb. Its main manifestations are resting tremor, muscle tonus, reduced or slowed movements, and postural balance and gait disturbances. Usually, after 3-5 years from the time of diagnosis, patients will be on 2-3 medications and experience varying degrees of reduced efficacy or side effects of the medication. The patient’s quality of life is also subsequently affected to a greater extent when xerostomia, end-of-season phenomenon, switching phenomenon, etc. occur. At this time, doctors often recommend that patients be evaluated for surgery and receive surgical treatment in due course. However, due to the progressive nature of Parkinson’s disease, the disease will gradually worsen, so patients with significant improvement in symptoms controlled by levodopa-based drugs can undergo surgery as early as possible, and patients can resume normal life and improve their quality of life after surgery. With little effect of medication control of Medobar, further preoperative evaluation is needed to determine whether there is an opportunity for surgical treatment. The preoperative evaluation mainly assesses two points: 1, whether it is suitable for surgery; 2, whether it can tolerate surgery; for whether it is suitable for surgery need to do: cranial MRI, Medobar shock test, disease progression assessment (previous disease, medical history analysis; Parkinson’s disease development rate and changes in symptoms are also important assessment factors); mental psychological scale assessment; for the assessment of whether it can tolerate surgery, need to do electrocardiogram, liver and kidney function To ensure that the patient can tolerate the surgery, electrocardiogram, liver and kidney function tests are required. The principles of initial drug therapy for Parkinson’s disease should be aimed at achieving effective improvement of symptoms and quality of life. Treatment should follow evidence-based medicine and should also emphasize individualized features. The selection of medication for different patients needs to take into account the patient’s disease characteristics and age of onset, employment status, presence of co-morbidities, possible side effects of medications, patient’s willingness, affordability and other factors, and start taking small doses to avoid, delay or reduce side effects and motor complications of medications as much as possible.