Chronic atrophic gastritis is a type of chronic gastritis, caused by chronic inflammatory lesions of the gastric mucosa from various causes. This chronic gastritis is accompanied by atrophic changes of the gastric mucosa, while type C2 means that the atrophy of the gastric mucosa extends from the gastric sinus to the gastric horn. Patients with chronic atrophic gastritis should be treated with symptomatic medications given for clinical symptoms, and medications that inhibit gastric acid secretion should be used with caution. Patients with chronic atrophic gastritis caused by H. pylori infection should be given regular H. pylori eradication treatment under the guidance of a gastroenterologist, currently recommended as quadruple therapy and PPI, bismuth plus two antibiotics. If HP infection does not exist, treatment is based on gastric mucosal protective agents, and symptomatic medication can be given according to the corresponding clinical symptoms, such as indigestion can be used to promote gastric emptying drugs or drugs to help digestion. Patients with chronic atrophic gastritis, whether type C1, C2 or C3, are recommended to be followed up closely.