Numbness and a burning sensation in the ankle and foot is a sign of neuropsychiatric symptoms in patients with foot problems. Foot disease, also known as vitamin B1 (thiamine) deficiency disease, is one of the common nutrient deficiency diseases. If the neurological manifestations are predominant, it is called dry pediculosis, and if the heart failure manifestations are predominant, it is called wet pediculosis. The former manifests as ascending symmetrical peripheral neuritis, sensory and motor disorders, decreased muscle strength, foot droop and toe droop in some cases, and cross-threshold gait when walking. The latter manifests as weakness, fatigue, palpitations, shortness of breath, etc. The diagnosis is mainly classified according to the following manifestations. 1, dry foot disease manifested as ascending symmetrical peripheral neuritis, sensory and motor disorders, muscle strength decreased, muscle pain to gastrocnemius muscle is heavy, some cases occur foot droop and toe droop, walking with a cross-threshold gait. The vagus nerve is the most severely damaged among the brain nerves, followed by the optic nerve and the motor nerve. In severe cases, hemorrhagic upper cerebral pallidum syndrome or cerebral pedalgia can be seen, manifesting as nystagmus, amnesia, disorientation, ataxia, impaired consciousness, and coma. It can also co-exist with Korsakoff syndrome with severe memory and disorientation dysfunction. 2. Wet foot disease manifests as weakness, fatigue, palpitations, and shortness of breath. Patients present with anorexia, nausea, vomiting, dysuria and peripheral edema due to right heart failure. Positive signs on physical examination are mostly signs of high venous pressure in the body circulation. The pulse rate is rapid but rarely exceeds 120 beats per minute, blood pressure is low but pulse pressure is increased, and gunshot sounds can be heard in the peripheral arteries. The relative turbid borders of the heart on percussion may be normal or mildly to severely enlarged. A gallop rhythm can be heard in the apical region, a mid-systolic murmur in the precordial region, wet rales in the base of both lungs, and signs of hepatomegaly, pleural effusion, peritoneal effusion and pericardial effusion can be detected. 3.Acute fulminant cardiovascular pediculosis manifests as acute circulatory failure, shortness of breath, irritability, decreased blood pressure, severe peripheral type cyanosis, rapid heart rate, marked heart enlargement, and jugular vein anger. Patients may die of acute heart failure within hours or days.