Most patients can be cured after reasonable treatment for ankle sprain, but there are also some patients who have lateral foot pain left after the disappearance of ankle pain, which is not cured for a long time, even up to several decades, affecting walking and labor. Usually, it is caused by the simultaneous injury of soft tissues in the tarsal sinus. The tarsal sinus consists of the talus groove and the heel groove, the sinus opening is located below the anterior aspect of the ankle, and the sinus contains the interosseous heel-talus ligament, the fat pad, and the synovial membrane and bursa of the heel-talus joint. Sprain of the ankle can cause injury to the ligaments, fat pads and synovial membrane in the tarsal sinus, resulting in aseptic inflammation, scar contracture and ligamentous tension after healing of the injury, resulting in lateral dorsal pain and tenderness at the opening of the tarsal sinus, sometimes radiating to the toes. Soft tissue lesions cause vegetative nerve dysfunction. Abnormal sensation in the calf and foot, coldness, sinking tightness, weakness and involuntary shivering occur. The pain can disappear immediately after using local closure of the sinus. Attention should be paid to rest after ankle sprain, local physiotherapy treatment, closed treatment can be used. The therapeutic effect is good. If conservative treatment is ineffective and the pain is persistent, surgery can be used to remove the soft tissues in the tarsal sinus, and gelatin sponge can be inserted into the tarsal sinus to stop bleeding and eliminate the dead space.