Artificial joint replacement is indicated for patients with severe joint pain, instability, deformity, severe limitations in daily life and activities, and where conservative treatment has been ineffective or ineffective. There are various diseases that can be treated with artificial knee replacement. Knee joint destruction, knee valgus or flexion contracture deformity caused by trauma, osteoarthritis, ankylosing spondylitis, rheumatoid arthritis, etc. can be treated with artificial knee replacement. Active infection, tuberculosis, and severe muscle and nerve dysfunction in the knee joint are not suitable for artificial knee replacement. The optimal age for knee replacement is 60-70 years old, but with the continuous development of modern artificial joint technology and improved surgical techniques, there is a trend toward younger age of joint replacement. Age is not the primary consideration for knee replacement, but is determined by the patient’s health status and the degree of knee pathology.