Congenital diaphragmatic bulges are caused by weakness of the diaphragm due to incomplete or non-muscularization of the thoracoabdominal membrane during the embryonic period, where the transverse muscles of the diaphragm are absent or extremely degenerated, especially the central tendon portion is replaced by extensive fibroelastic tissue. It can be further divided into 3 categories: complete, partial and bilateral. In children with diaphragmatic bulge, congenital pulmonary dysplasia and gastric torsion may be associated. So, how can congenital diaphragmatic expansion be prevented? 1, maternal health The occurrence of some immunodeficiency diseases are known to be closely related to embryonic dysplasia, if a pregnant woman is exposed to radiation, treatment with certain chemicals or viral infections (especially rubella virus infection), etc., can damage the fetal immune system, especially in early pregnancy, including the immune system, multi-system involvement, it is important to strengthen maternal health care, especially early pregnancy health care Therefore, it is very important to strengthen maternal health care, especially in early pregnancy. Pregnant women should avoid receiving radiation, use some chemical drugs carefully, inject rubella vaccine, etc., and prevent viral infections as much as possible. 2, genetic counseling and family investigation Although most diseases can not determine the mode of inheritance, but the genetic counseling of the disease to determine the mode of inheritance is very valuable, if adults with hereditary immunodeficiency disease will provide their children’s developmental risk; if a child with autosomal recessive or sex-linked immunodeficiency disease, parents should be told how likely their next child has the disease. Immediate family members of patients with antibody or complement deficiencies should be tested for antibody and complement levels to determine the familial mode of disease, and for certain diseases for which genetic localization has been possible, such as chronic sarcoidosis, the patient’s parents, siblings, and their children should be tested for localized genes, and if a patient is found, he or she should likewise be examined in his/her family members, and the patient’s children should be carefully monitored for disease from birth The children of the patient should be carefully observed for the occurrence of the disease from birth. 3, prenatal diagnosis Certain immunodeficiency diseases can be prenatally diagnosed, such as the culture of amniotic fluid cell enzymology can be diagnosed adenosine deaminase deficiency, nucleoside phosphorylase deficiency and certain combined immunodeficiency diseases; fetal blood cell immunology test can be diagnosed CGD, X-linked gammaglobulinemia, severe combined immunodeficiency disease, so as to interrupt pregnancy and prevent the birth of affected children.