Pancreatic cystic tumor with segregation indicates the presence of segregation within the lesion, which may be fibrous, inflammatory or substantial, and the details need to be judged according to the condition. Pancreatic cystic tumors are divided into true cysts, pseudocysts and cystic tumors, and patients will have symptoms such as abdominal distension, epigastric discomfort, mass, pressure pain, etc., and patients should take timely treatment. If the enhanced CT suggests that the tumor intensification is obvious, with more segregation, thicker segregation, intensification of segregation or uneven segregation with nodules, then malignant transformation should be considered, and rapid frozen pathological examination is usually needed for surgical resection. Patients with pancreatic cystic tumor can be treated with surgery according to the doctor’s instruction, and the common surgical methods include splenectomy, pancreatic caudal resection, pancreaticoduodenectomy, and simple tumor removal. The prognosis of patients after timely treatment is good, but if not treated in time, the tumor may become malignant and the prognosis is poor. It is suggested that patients should seek medical treatment in time and follow the doctor’s instructions to avoid aggravating the condition.