When the following 12 symptoms appear on the body, it is best to pay attention to them and promptly seek medical advice to rule out potential medical conditions. 1. Spontaneous ulcers that do not heal for more than 1 month without trauma to any part of the body; 2. Any part of the body that has recently developed a swelling that is gradually increasing in size; 3. Irregular vaginal bleeding or increased leucorrhea; 4. Lump in the breast or bloody fluid discharged from the nipple; 5. Feeling of obstruction in swallowing or burning sensation behind the sternum; 6. Progressive loss of appetite and upper abdominal discomfort; 7. Dry cough or blood in sputum; 8. There is nosebleed, unilateral nosebleed or posterior aspiration with blood; 9. Blood in the stool or abnormal defecation, painless hematuria; 10. Progressively worsening headache, especially with vomiting and visual disturbance; 11. Persistent hoarseness; rapid enlargement of nevus or ruptured bleeding; 12. Unexplained progressive weight loss.