What are the common tumor markers of lung cancer? Primary bronchopulmonary cancer (lung cancer for short), which refers to cancer that originates in the bronchial mucosa and alveoli, is one of the common malignant cancers. The occurrence of this disease is mainly affected by chemical carcinogens, and smoking is one of the main causes. In addition, industrial waste gas and air pollution, which produce a lot of polycyclic aromatic hydrocarbons and other harmful gases, can also induce lung cancer. Most lung cancers occur between the ages of 35/75. There are more men than women. Tumor markers for lung cancer include the following: Carcinoembryonic antigen (CEA) CEA is a fetal protein found in adult cancer tissues, and CEA was discovered in 1965. It is an acidic glycoprotein that is synthesized in the small intestine, liver, and pancreas during embryonic life and is present in very low levels in adult serum (generally <5 mg/L). It can be detected by immunological methods. It was initially thought to be a marker for colon cancer (elevated in 60-90% of patients), but has since been found to be highly expressed in pancreatic (80%), gastric (60%), lung (75%) and breast (60%) cancers. CEA measurement is a useful indicator for the diagnosis of cancer, prognosis, and recurrence prediction. Neuron-specific enolase (NSE) 1. It can be used as an aid in the diagnosis and monitoring of the therapeutic effect of small cell lung cancer. NSE concentration gradually decreases to normal level when treatment is effective, and increases when recurrence occurs. Monitoring recurrence by elevated NSE is 4-12 weeks earlier than clinical determination of recurrence. 2.It can be used to monitor the change of neuroblastoma, evaluate the efficacy and forecast the relapse. 3.Serum NSE may also be increased in endocrine tumors, such as pheochromocytoma, islet cell tumor, medullary thyroid carcinoma, melanoma, retinoblastoma, etc. Normal reference value: serum <15ug/L. Squamous cell carcinoma antigen (SCC) SCC is a marker of squamous epithelial carcinoma, and SCC is elevated in all kinds of squamous carcinomas. The positive rate of lung squamous carcinoma is 46-90%, and the concentration of SCC in serum increases with the aggravation of the disease. Normal reference value: serum <2ug/L. Glycoantigen 125 (CA125) can be elevated in malignant tumors such as lung cancer, ovarian cancer, endometrial cancer, fallopian tube cancer, pancreatic cancer, gastric cancer, breast cancer, esophageal cancer, etc. Normal reference value: <35KU/L Cytokeratin 19 fragment (CyFRA21-1) CyFRA21-1 is a new marker for lung squamous epithelial cell carcinoma and non-small cell lung cancer, and is significantly elevated in patients with lung squamous epithelial cell carcinoma with a sensitivity of 70% specificity of 95%. It is important for the early diagnosis of non-small cell lung cancer to observe the efficacy and prognosis. In general, tumor markers for lung cancer can be selected from CEA, CA125, NSE, SCC, CyFRA21-1, etc., either singly or in combination, especially if several indicators are combined for better results.