The reason for coughing worse with medication may be related to the progression of the disease and the use of the wrong medication, such as mycoplasma pneumonia and chlamydia pneumonia, where oral amoxicillin and cephalosporin anti-inflammatory drugs are ineffective, thus leading to the progression of the disease and worsening of cough symptoms. In addition, if the degree of lung infection is more severe, oral anti-infective drugs are difficult to control their condition, thus aggravating the cough, and patients need intravenous drip treatment with sensitive anti-infective drugs at this time. In the case of lung cancer, oral medication is also ineffective and the degree of cough worsens due to the progression of lung cancer. In the case of cough variant asthma, oral cough medication alone may also be ineffective, and the patient will need treatment with inhaled glucocorticoids. Therefore, patients with cough should be treated in a standardized manner in the respiratory department for the cause of the cough in order to better control the disease and relieve clinical symptoms.