I. Understanding Parkinson’s disease Parkinson’s disease is a neurological disorder commonly seen in middle-aged and elderly people, with three main manifestations, namely tremor, limb stiffness and motor slowing. It is now known that Parkinson’s disease is a degeneration of a part of the brain called the substantia nigra striata, resulting in a decrease in the production of dopamine substances and the above manifestations. The three main symptoms can exist in one patient at the same time, which is medically called mixed Parkinson’s disease, but not every patient has the three main symptoms, especially in the early stage, some only have tremor or tremor mainly, so it is called tremor type; some only show limb stiffness, but no tremor, so it is called rigid type; some mainly show motor retardation, so it is called motor retardation type. The disease is not easily detected or diagnosed at the beginning because the symptoms are not obvious or single. The onset of the disease is usually in one or one of the limbs, and over time it spreads to the opposite limb. The tremor type is easily diagnosed early and is characterized by calm or inattentive tremors that stop with activity, holding or concentration, called resting tremor, but this feature may disappear in advanced stages of development. The rigid type is the most easily misdiagnosed. Early on, it only shows inflexibility of one limb, and some only swing one hand when walking, but not the other hand, and they only realize it when they are found by others, then they can go to the hospital for examination and find increased muscle tone, which can make the initial diagnosis. Patients with motor retardation mainly have difficulty starting called frozen feet and walk slowly. The symptoms of Parkinson’s disease will gradually worsen over time, and in the middle and late stages, in addition to the above symptoms, the patient will have a dull expression, stooped back, accompanied by slurred speech, poor speech, drooling, insomnia, pain in the limbs, easy sweating, poor urination and defecation and even depression and other mental symptoms, and gradually lose the ability to take care of themselves. Second, the choice of medical treatment Early if the symptoms are mild and do not affect the function, you can temporarily do not use anti-Parkinson’s disease drugs. The main thing is to exercise more and strengthen the exercise. Vitamin E, coenzyme Q10, etc. can be taken. Those who are financially able can apply B-type monoamine oxidase inhibitor – Silanginin treatment. Anti-Parkinson’s disease drugs should be considered when symptoms are more pronounced and affect motor function, but they must be used under the guidance of a specialist. The principle is to keep the dose as small as possible, not to seek full effect, and to keep the water flowing. Initially, non-dopaminergic drugs such as amantadine can be used, and tremor can be used mainly for Antan. However, these drugs should be used with caution in patients over 65 years of age, as they can cause cognitive dysfunction. If the desired goal is not achieved or symptoms worsen after the above mentioned medications, two types of medications are considered to be applied: (i) dopamine agonists, such as Senfuro, Cripa, and Tysudar. (ii) dopamines, such as levodopa, methyldopa, and xylazine. For dopamine drugs appearing switch phenomenon or end-of-dose phenomenon can be added to the treatment with entacapone (Cordain). Many patients in the middle and late stages of Parkinson’s disease can not avoid the loss of drug efficacy and serious complications, such as isokinetic disorder, switching phenomenon and end-of-dose phenomenon. Appropriate surgical treatment is a good choice, although it can not cure the cause of the disease but can significantly improve the symptoms, improve the quality of life, reduce the amount of drugs, to extend the life of the purpose. There are two mature techniques: one is stereotactic radiofrequency (cytoknife). “Cell knife” is a surgical system, the procedure is: CT, MRI scan, computer for surgical planning, local anesthesia on the top of the head to cut a small 2cm incision, a hair-sized microelectrode needle into the brain, accurate measurement of the brain only the size of sesame seeds “tremor rigid cell cluster “The tremor will stop immediately and the stiff limbs will be flexible, because the technique reaches the cellular level, so it is called “cellular knife”. It is a minimally invasive and effective treatment for Parkinson’s disease, as the patient is awake and painless during the operation, and can eat and get out of bed the next day. The second is the installation of a brain pacemaker or deep brain stimulation (DBS). Pacemaker is the application of “cell knife” micro-electrode positioning technology, stereotactic stimulation electrodes into the brain inner nucleus, through the wire side of the brain a match large pulse transmitter, through the emission of a certain frequency of pulse stimulation to achieve the purpose of treatment. This is the most advanced surgical treatment for Parkinson’s disease. Regardless of which methods of treatment are chosen, patients should pay attention to the following points: 1. Be optimistic and confident in overcoming the disease. 2. Insist on more brain use, more activities, and do something within your ability and exercise every day without interruption, which can significantly slow down the progress of the disease. 3. Eat more vegetables and easily digestible food, and do not take vitamin B6. 4. If you have sleep disorders or constipation, it is recommended to see a relevant doctor for assistance. Treatment.