A rare pancreatic tumor that occurs in young women: Pancreatic Solid Pseudopapillary Tumor A fifteen-year-old high school girl, Xiao Xiao, told her mother one day that she inadvertently felt a lump on her upper abdomen, which did not hurt, did not itch, and did not interfere with her meals. Her mother took her to the hospital for a checkup. When they heard that the doctor told them that there was a tumor on the pancreas and it was very big. She was very scared and went to a big hospital in the provincial capital to ask what happened. After further CT examination, the tumor was basically identified as solid pseudopapillary tumor of pancreas. They were still confused, and finally went to the hepatobiliary and pancreatic surgery clinic to learn more about this rare pancreatic tumor. The exact origin of solid pseudopapillary tumor of the pancreas has not been clarified. However, it is most commonly seen in female patients, especially in young adult women, and is rare in men. It can be found anywhere in the pancreas. It may cause vague pain and discomfort in the upper abdomen; if there is internal bleeding, it may be accompanied by severe abdominal pain, nausea and vomiting and other gastrointestinal symptoms. Some patients have no obvious discomfort even if the tumor is very large in size, but just touch it by chance or find the pancreatic mass during normal checkup. It is usually not accompanied by discomfort such as jaundice or loss of physical strength. Blood test results are usually normal. Experienced physicians can basically confirm the diagnosis of this disease based on ultrasound and CT examination, and can distinguish it from other benign and malignant tumors of the pancreas based on the clinical symptoms and signs and the characteristics of imaging manifestations. This tumor is different from pancreatic cancer, although it is mostly recognized as a kind of low malignant tumor, but metastasis and invasion of surrounding tissues and organs rarely occur, and recurrence or metastasis after complete resection is rare, so it is recommended to treat it with aggressive surgical resection, but rapid frozen pathological examination should be carried out in order to clarify the diagnosis as much as possible and to determine the surgical treatment plan. According to the location and size of the tumor and its relationship with the surrounding tissues, simple tumor resection, pancreatic segmental resection including the tumor, pancreatic head tumor resection with preservation of duodenum, pancreatic body tail tumor resection with preservation of spleen, or pancreatic duodenal resection and pancreatic body tail resection including the spleen can be performed. If tumor metastasis occurs, the metastatic lesion may be resected at the same time. For experienced pancreatic surgeons, the surgical risk can be essentially minimal. The patient’s postoperative recovery is generally uneventful. If postoperative pathology confirms the diagnosis, it can be reviewed periodically. Unlike other malignant tumors, postoperative radiotherapy is not required. Little mother and daughter listened to the doctor’s introduction, finally put down their hearts and determined the surgical treatment program. Finally, under the doctor’s careful treatment, she successfully recovered and was discharged from the hospital. Based on the successful completion of dozens of cases of this kind of pancreatic tumor, the Department of Hepatobiliary and Pancreatic Surgery of Shandong Provincial Hospital has summarized a more perfect surgical method according to the pathology and clinical manifestations of this tumor, and achieved a good therapeutic effect. Although this tumor is large in size, it is very different from pancreatic cancer. It mostly occurs in young patients, usually has complete periphery and less invasion of neighboring tissues, organs and blood vessels, shows convex growth, and rarely recurs and metastasizes after tumor resection, etc. Therefore, we explicitly suggest that we try to perform less traumatic surgery such as local resection or pancreatic segmental resection of the tumor. If the tumor is located in the head of pancreas or the tail of pancreas, we can try to perform pancreatic head resection with preservation of duodenum or tail resection of pancreas with preservation of spleen, so as to minimize the surgical trauma and ensure the normal anatomical and physiological functions of the patients, and the patients will recover more quickly after the operation, and the cost of treatment will be reduced accordingly. Papers from our department on the diagnosis and new concepts of surgical treatment of this tumor have been published in international and national journals.