AIDS can itch. AIDS is also known as acquired immunodeficiency syndrome, which is a chronic infectious disease caused by human immunodeficiency virus infection that eventually leads to a decline in the body’s immune function and causes infections leading to multiple organ involvement and death. Therefore, AIDS patients with reduced immune function, low resistance and reduced local defense can have allergic reactions with endogenous and exogenous allergens, and the skin can show allergic symptoms and manifest itchy skin. In addition to symptomatic treatment with antiviral drugs, anti-allergy drugs such as paracetamol and cetirizine hydrochloride can be given to treat the itchiness of patients.