Malassezia furfur, also known as Malassezia, is a fungal infection that can usually be cured but is prone to recurrence and difficult to eradicate. The onset of Malassezia furfur infection is mostly in the 30s, more in women than in men, and occurs on the back, chest, neck, face and shoulders, etc. It is mostly a follicular inflammation, manifesting as follicular red papules, papules or small pustules, etc., 2-4 mm in diameter, with pustules, and distributed in pairs. It may be accompanied by itching, stinging or burning sensation, and a wind-blown and flushed reaction often occurs when scratching. Depending on the site of action, S. furfur infection can also cause seborrheic dermatitis, lichen planus, and other diseases. After the infection of Sphaerococcus furfur, the treatment is based on topical antifungal drugs, such as sulfur ointment and azole drugs. In addition to antifungal treatment there is also a need to use immunomodulatory drugs, such as high-dose oral thymidine, etc. There is also a need to reduce the secretion of skin oil. The high secretion of skin sebaceous glands is mostly related to the patient’s own high androgen secretion, which can be relieved by oral anti-androgenic drugs such as spironolactone and cimetidine. In order to prevent the recurrence of Sphaerococcus furfur infection, it is necessary to keep the working environment ventilated, reduce sweating, pay attention to skin cleanliness, and avoid self-administration of broad-spectrum antibiotics and glucocorticoids.