Mouth bitterness after the application of drugs for the treatment of H. pylori is a normal phenomenon, and the symptoms can generally be gradually relieved after discontinuing the drug. Common causes 1, adverse drug reactions: anti-H. pylori drugs are generally quadruple drugs, including omeprazole, amoxicillin, clarithromycin, colloidal pectin bismuth, etc., of which clarithromycin can cause changes in taste and significant side effects such as bitterness in the mouth and decreased appetite; 2, gastric diseases: H. pylori infection can cause gastritis, decreased gastric power, the main symptoms are bile reflux, indigestion, bad breath, etc., and may also cause bitterness in the mouth during the treatment process. Treatment 1, if in the process of medication appeared bitter mouth phenomenon, can tolerate the case, can adhere to complete a course of antibacterial therapy, if not tolerated, can be replaced by clarithromycin oxyfloxacin, minocycline and other antibacterial drugs to complete treatment, otherwise stop midway can not completely cure H. pylori infection; 2, for bile reflux can be applied domperidone, mosapride to enhance gastric motility, reduce reflux, magnesium aluminum carbonate adsorption. Reduce reflux, magnesium aluminum carbonate adsorption bile, thus reducing the phenomenon of bitter mouth. Caution patients with bitter mouth after taking medication, should not suspend drug treatment on their own, you can follow the doctor’s instructions to change the drug.