Chemotherapy is currently the main treatment for pediatric leukemia, but chemotherapy drugs have strong gastrointestinal reactions and bone marrow suppression and other toxicities and side effects, and many patients cannot tolerate chemotherapy and have to interrupt. Some patients die because of the rapid decline of white blood cells after chemotherapy and the extremely low resistance of the body, as a result, the infection is difficult to control. By using the idea of “treating the disease before it occurs” of Chinese medicine, the adjuvant treatment with Chinese medicine during chemotherapy can reduce the toxic side effects of chemotherapy drugs, improve the patient’s tolerance to chemotherapy drugs, ensure the smooth implementation of the chemotherapy program, and enhance its therapeutic effect, Thus, the success rate of chemotherapy can be improved and remission can be induced. Before chemotherapy, we used double tonification of qi and blood, benefiting qi and nourishing yin, and tonifying yin and yang to treat anemia; nourishing yin and clearing heat, clearing heat and relieving symptoms, and clearing heat and detoxifying toxins to treat fever; benefiting qi and regulating blood, clearing heat and cooling blood, and resolving blood stasis to stop bleeding; activating blood circulation and resolving phlegm to remove stasis to treat extra-marrow infiltration symptoms. During chemotherapy, the treatment of gastrointestinal symptoms caused by chemotherapy was carried out by strengthening the spleen and stomach, harmonizing the stomach and lowering rebelliousness, and detoxifying the liver and spleen, respectively; clearing heat and dampness to reduce yellowing, and warming the middle and spleen to reduce yellowing to treat jaundice caused by abnormal liver function. After chemotherapy, nourishing the liver and kidney and warming the spleen and kidney were used to treat bone marrow suppression respectively. The common clinical manifestations include nausea, vomiting, abdominal distension, loss of appetite, depression, back pain, hair loss, decrease in white blood cell count, low body resistance, and easy infection. Chinese medicine treatment at this stage is aimed at supporting the righteousness and correcting the toxic side effects of chemotherapy drugs, so that patients can safely pass through chemotherapy. The main treatment is to strengthen the spleen and benefit the qi, accompanied by resolving dampness, detoxification and eliminating blood stasis. The basic formula is Six Jun Zi Tang with addition and subtraction, which consists of 15-30 g of Radix et Rhizoma Ginseng, 6-12 g of Atractylodes Macrocephala, 15-20 g of Poria, 3-5 g of Pericarpium Citri Reticulatae, 5-8 g of Radix et Rhizoma Fasciculatae, 5-9 g of Perilla, 5-9 g of Patchouli, 3-6 g of Cardamom, 15-30 g of Rhizoma Alba, and 3-5 g of Glycyrrhiza glabra. Addition and subtraction: If the deficiency of qi is very serious, add 3-6g of raw ginseng or 6-9g of American ginseng; if the deficiency of kidney is obvious, add 12-18g of mulberry, 9-15g of codonopsis and 9-12g of lady’s mantle; if the deficiency of resistance is obvious, add 5-8g of Cordyceps sinensis and stew. 1.2 Chinese medicine treatment in the interval phase of chemotherapy In the interval phase of chemotherapy, we should make full use of the advantages of Chinese herbal medicine with less toxic side effects, and play the positive role of Chinese herbal medicine to inhibit the active proliferation of white blood cells in this phase. In this stage, the treatment of TCM is mainly to eliminate the evil, and the treatment is mainly to clear heat and detoxify, remove blood stasis and fight cancer, with a little support of strengthening the spleen and helping the righteousness. Basic formula: 15~30 g of Cyperus alba, 15~30 g of Radix et Rhizoma half-stem, 15~30 g of Phellodendron stoloniferum, 1~3 g of Qing Dai, 1~2 centipedes, 6~9 g of Curcuma longa, 12~18 g of Poria, 15~20 g of Poria, 15~30 g of Radix et Rhizoma prunus, 3~5 g of Glycyrrhiza glabra, Decoction: 1 dose per day in water, taken at once. With the oral Chinese medicine Six Gods Pill, each time 5-10 capsules, 2~3 times a day. Addition and subtraction: For hepatosplenomegaly, add 6-10g of Andrographis paniculata (first decoction), 10-15g of turtle shell (first decoction), 3-6g of ground turtle worms; for joint pain, add 10-18g of white peony, 12-18g of mulberry branch, 10-15g of Chuanxiao; for subcutaneous hemorrhage, remove Curcuma longa, add 12-18g of white foxglove, 10-15g of Phellodendron leaf, 10-15g of lotus root, and take Yunnan Baiyao orally. The formula is used in combination with oral administration of Yunnan Baiyao, 0.25g each time, 4 times a day. The basic formula of Fu Zheng is made by adding flavor to the ancestral formula of Six Jun Zi Tang, which is a mild and pacifying formula to benefit the qi and strengthen the spleen, and replacing the ginseng with prunus ginseng to make the formula more pacifying. The addition of an anti-cancer herb, Bupleurum, aims to treat both the symptoms and the root cause, and can control the warmth and dryness of the dampness and spleen medicine. The modern pharmacological research has concluded that this product has a strong anti-infective effect, which can improve the bactericidal effect of serum and increase the phagocytosis of leukocytes, and has a certain inhibitory effect on leukemia in large doses, which is a rare product that can both treat leukemia and prevent infection, and has the wonderful effect of attacking the evil without hurting the positive. In the selection of resistance and anti-leukemia herbs, it is appropriate to take advantage of the modern pharmacological research results of herbs: ginseng not only regulates the immune function of the body, and has a certain degree of anti-tumor effect; Cordyceps can significantly improve the immune function of the body, and can improve the NK cell activity of leukemia patients, and has a better anti-tumor effect; some herbs such as seven leaves a flower, shanzu root, pig calamus, sheep’s trotter, comfrey, groundnut, and so on. Some herbs, such as Pseudostellaria, Pseudostellaria, Compositae, Curcuma, etc., have certain anti-leukemic effects in pharmacological studies. At present, several studies have proved that many herbal medicines have anti-cancer effects, such as herbal medicines for activating blood circulation and resolving blood stasis, herbal medicines for clearing heat and detoxifying toxins, and herbal medicines for tonicity, etc. The toxic herbal medicines Qing Dai, Xiong Huang and Arsenic have been proved to have good therapeutic effects on acute promyelocytic leukemia at home and abroad. Clinical and experimental studies have shown that compound Qing Dai tablets have significant leukemia cell killing effect, and the effect appears quickly. Liushenwan not only has anti-leukemia effect, but also can prevent and control infection. The combination of blood-activating drugs and chemotherapy can enhance the killing power of chemotherapy drugs on cancer cells, strengthen the body’s humoral immunity and the phagocytosis function of macrophages, improve the hypercoagulable state of blood, facilitate the chemotherapy drugs to reach the disease, reduce the toxic side effects of chemotherapy drugs, and thus improve the efficacy.