In the treatment of coronary heart disease, aspirin is credited with inhibiting platelet aggregation and is commonly used in the secondary prevention of atherosclerotic cardiovascular disease. However, if you read the instructions carefully, you will find that low doses of aspirin reduce the elimination of uric acid and can induce gout. So, can patients with cardiovascular disease combined with elevated blood uric acid take aspirin anymore? Aspirin, at first, was not a cardiology drug, but an antipyretic and analgesic drug, mainly used for fever caused by the common cold or influenza, but also for the relief of mild to moderate pain, such as headache, joint pain, toothache, muscle pain, etc.. The general dose of its antipyretic and analgesic for adults is usually 1 gram-2 grams/day, while anti-rheumatic is used to 3-5 grams/day. This is all Later it was found that small doses of aspirin have anti-platelet aggregation effect, and now it is mainly used in secondary prevention of vascular embolic diseases such as myocardial infarction and cerebral infarction. And its use for antipyretic and analgesic effects often causes stomach upset and peptic ulcers, so it has been replaced by newer non-steroidal drugs. The effect of aspirin on uric acid metabolism is related to its drug dose. At high doses of aspirin (>3g/day), it significantly inhibits the reabsorption of uric acid by the renal tubules and promotes uric acid excretion; at small to moderate doses of aspirin (<1-2g/day), it inhibits the excretion of uric acid by the renal tubules, thus causing an increase in blood uric acid levels. Generally 75-325mg/day of aspirin (small dose) is the only one that has good anti-platelet effect, relatively small side effects and beneficial to heart vessels, so it is not recommended to discontinue it for patients with combined hyperuricemia, and can be taken while drinking more water or alkalinizing urine, as well as closely monitoring blood uric acid level. And in case of acute phase of gout, temporary discontinuation is considered. Most statins have a weak pro-uric acid excretory effect, which can partially offset the mild elevation of blood uric acid caused by aspirin. Therefore, whether aspirin can be taken in patients with coronary artery disease combined with high uric acid needs to be analyzed on a case-by-case basis, do not stop taking it without permission!