Parkinson’s disease patients are mostly middle-aged and elderly people, with ageing, their body functions gradually decline, and their immunity also declines. Therefore, the elderly are also prone to cardiovascular diseases, such as hypertension, diabetes, coronary heart disease, etc., and need to take long-term medication to control their condition. Elderly people in order to enhance the resistance, usually also like to buy some health care products to take, such as calcium tablets, vitamins and so on. Because the drugs are chemical agents, the most worried about each other to cause adverse reactions, then Parkinson’s disease drugs can not be combined with which drugs? 1, rifampicin and its compound preparations (such as compound rifampicin tablets, adaphene, hypotension, hypotension static, hypotension level, etc.) should be avoided, because this drug can increase the depletion of dopamine in the dopamine neuron terminal capsule. In hypertensive patients without Parkinson’s disease, long-term, large amounts of drugs may also cause Parkinson’s syndrome. 2, valium and phenothiazine drugs: can antagonize the effect of levodopa, should try to avoid using, including chlorpromazine, fenestrazine, fluorine fenestrazine, promethazine and so on. These drugs can cause Parkinson’s syndrome and postural hypotension, so should not be applied at the same time. 3, tricyclic antidepressants: such as amitriptyline, amoxapine, chlorpromazine, etc. Although it can strengthen the therapeutic effect of levodopa, but it can cause cardiac rhythm disorders, especially the elderly patients are more likely to appear, should be avoided. 4, non-selective monoamine oxidase inhibitors, the drugs can hinder the inactivation of dopamine and other catecholamines, so that the accumulation of dopamine in the blood, resulting in elevated blood pressure, and even produce hypertensive crisis and high fever. Therefore, stop using these drugs, such as eugenol, isocarboxazid, phenelzine, etc., at least 2 weeks in advance before using levodopa. In contrast, B-type monoamine oxidase inhibitors (e.g., Siginine or Kinspin, at a daily dose of 20 mg or less) generally do not cause an increase in blood pressure. Finally, Parkinson’s disease patients also suffer from other diseases, must pay attention to the use of drugs, some Parkinson’s disease drug side effects can also cause tachycardia, blood pressure drop and other problems, so the patient visits the clinic, try to give a detailed account of the condition, so that the doctor can accurately adjust the medication, in addition, a variety of diseases when taking medication, should be bifurcated to take the time, to avoid causing strong side effects.