Children hives at night is mainly caused by allergies, you can take oral anti-allergy drugs and local application of topical ointment for treatment. 1. Oral anti-allergic drugs: children hives at night can be applied to loratadine, cetirizine and other antihistamines to relieve the allergic reaction. 2. Local application of topical ointment: ① can be applied locally with antipruritic effect of glycerite lotion. ② topical application of glucocorticoid cream, such as Dinaid cream, with anti-inflammatory, anti-allergic, anti-itch and other effects. The above anti-allergic drugs exist in different degrees of adverse reactions, such as drowsiness, dizziness, skin irritation, etc. When using these drugs, be sure to follow the doctor’s instructions strictly under the guidance of the doctor. In addition to pay attention to the hygiene and cleanliness of the living environment, and change clothes regularly. Try to avoid suspected allergens.