The time to cancer of gastric sinus intestinalization cannot be precisely determined clinically, and is related to factors such as whether clinical intervention is given or not. If the cause of the disease can be clarified, targeted treatment can be actively given, and regular review can be done, the risk of cancerous gastric sinus intestinalization can be reduced. Gastric sinus intestinalization is divided into two types: complete and incomplete. Complete sinus intestinalization is an inflammatory reaction and usually will not become cancerous; incomplete sinus intestinalization has a certain chance of becoming cancerous, but it does not mean that sinus intestinalization will definitely develop into cancer. The clinical consideration of sinus enterosis is caused by H. pylori infection, and the progress of enterosis can be delayed by H. pylori eradication treatment. Clinically, quadruple therapy can be used to eradicate H. pylori infection, that is, two antibiotics are selected, combined with proton pump inhibitors and bismuth agents for treatment, the specific drug selection needs to be individualized by the doctor according to the patient’s condition. In case of inflammation leading to sinus enterosis, the inflammation needs to be treated aggressively so as to reduce the risk of cancer. While cooperating with the doctor to receive clinical treatment, patients need to pay attention to changing bad eating habits, not to overeat, and avoid eating too cold, too hot, too hard or spicy stimulating foods. They also need to pay attention to ensure sufficient sleep and avoid overexertion. This will help to reduce the risk of cancer in sinus intestinalization.