Usually, oral hypoglycemic drugs for the treatment of diabetes mellitus do not always damage the liver and kidneys, but most of the drugs are metabolized by the liver and kidneys, so there may be some limitations for patients with liver and kidney insufficiency; insulin, comparatively speaking, is less demanding on liver and kidney function. Generally speaking, most of the oral hypoglycemic drugs are metabolized by the liver and kidneys, and most of them will not cause liver and kidney damage to patients with normal liver and kidney functions, but may aggravate liver and kidney damage to patients with abnormal liver and kidney functions. Insulin is usually not damaging to liver and kidney function. Side effects of insulin include hypoglycemia during glucose lowering. Patients with hyperglycemia are advised to consult an endocrinologist for treatment under the supervision of a doctor.