The statement “the nemesis of headache” is not true. There are various causes of headaches, such as mental stress and other physiological factors, neurasthenia, migraine and other disease factors. According to different causes, patients can follow the doctor’s instructions to use different ways of treatment, such as general treatment, drug treatment. 1. Physiological factors: mental stress, lack of sleep, head cold and other physiological factors can lead to headaches, it is recommended to maintain a stable, happy emotional state and adequate sleep, do a good job of keeping the head warm, you can massage the head, hot compresses, to relieve the pain. 2. Neurasthenia: long-term mental stress, mental work and other factors may induce neurasthenia, resulting in headaches. Patients can follow the doctor’s instructions oral fluoxetine, paroxetine, sertraline and other 5-hydroxytryptamine reuptake inhibitor drugs, is conducive to the improvement of the condition. 3. Migraine: Migraine may be induced by nerve cell excitability disorder and mental stress, resulting in headache, nausea and vomiting. Patients can take oral celecoxib capsules, ibuprofen, aspirin and other non-steroidal anti-inflammatory drugs as prescribed by the doctor to relieve headache symptoms. If the headache symptoms, to rule out physiological factors, it is recommended that the patient to the hospital to find out the cause of the disease, and then follow the doctor’s instructions on the cause of treatment.