Yang**, female, 54 years old, menopausal, with a family history of breast cancer. She was admitted to the hospital for “nipple overflow for one week”. Breast palpation was negative. Ultrasound did not show any abnormality; mammogram showed a cluster of abnormal calcifications in the upper part of the right outer breast, and the results returned: DCIS (BI-RAD grade V) was considered and surgical biopsy was recommended; breast ductoscopy results: ductal dilatation and plasmacytoid mastitis. After admission, surgical biopsy was performed under molybdenum guidance with guidewire positioning, and pathology confirmed intra-ductal carcinoma, and the patient was discharged with postoperative recovery without chemotherapy. Approximately 30% to 50% of breast cancers are associated with microcalcifications, and some of these breast cancer cases have no mass shadow and are definitively diagnosed solely on the basis of the typical malignant calcification features. Therefore, fine, granular clusters of microcalcifications are an important early manifestation of breast cancer. Calcifications on mammography images can be classified as sheet-like calcifications, cluster-like calcifications, and fine dot-like microcalcifications. The main morphology of malignant calcification foci are mucoid, bifurcated, and fine lines with blurred borders, often distributed along the ducts. The nature and extent of the lesion can be reflected according to the morphology, size, number and density of microcalcifications. Generally, microcalcifications can be located in or around the mass, with a total number of 6 to 15, with uneven density and varying size. The mammography guided wire localization biopsy of abnormal calcified foci in the breast has been commonly used in clinical practice abroad, but is not yet commonly used in China. Its application is mainly in cases where clinical palpation is negative and X-ray shows suspicion of malignancy. The method is simple, with few complications and high diagnostic accuracy, and it is worth promoting its use.