The principles of antiepileptic drug treatment for children are basically the same as those for adults, but the following features should be noted: 1. Referring to the standard weight for drug administration Rapid growth and development in childhood, the daily dose of drug should be calculated according to the standard weight range. 2, different drug metabolism ability Neonates and small infants liver and kidney function is not fully developed, the metabolism and excretion ability of drugs is poor, the half-life of drugs in the body is long, easy to accumulate poisoning; infants to preschool drug metabolism rate in the body is fast, the half-life is short, so the dose should be adjusted according to clinical efficacy under the drug blood concentration monitoring. 3.Monitoring of adverse drug reactions Pay attention to the monitoring of adverse drug reactions, regular liver function, blood tests, etc. Particular attention should be paid to the increased risk of liver damage of valproic acid in children younger than 2 years old or with genetic metabolic diseases. The first seizure medication should be started after the first seizure, taking into account the cause of the epilepsy, the type of seizure, and the epilepsy syndrome. For example, in benign infantile epilepsy, after the first cluster of seizures, antiepileptic drugs can be temporarily not used, continue to observe, and then start antiepileptic drug treatment if the interval of 24 hours between seizures. However, if the cause of the seizure persists, AEDs should be given after the first seizure, if there is a clear history of perinatal brain injury. Children are at an important stage of growth and learning. When choosing antiepileptic drugs, the impact on the child’s cognitive function should be fully considered and should be observed during the drug administration process. In addition to AEDs, adrenocorticotropic hormone and ketogenic diet can be used as special treatment for some special epileptic encephalopathies in childhood (e.g. West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, etc.). In addition, for children with mitochondrial disease and organic acidemia combined with epilepsy, valproic acid is likely to cause liver damage and should not be used as much as possible.