HPV is a human papillomavirus, a spherical DNA virus that causes squamous epithelial hyperplasia in the human skin mucosa. It is mainly transmitted through sexual contact, but can also be transmitted through indirect contact. The incidence has increased significantly in the last two years, and it is important to understand that the number after HPV indicates the model. There are many types of HPV viruses, high risk and low risk are said to be the chances of cancer. Skin high-risk types include HPV-5, 8, 14, 17, 20, 36, 38 and warty epidermal dysplasia, vulvar cancer, penile cancer, anal cancer, prostate cancer, bladder cancer, etc. are also related to HPV infection; mucosal high-risk types include HPV-16, 18, 30, 31, 33, 35, 39, this type is related to the development of cervical cancer, rectal cancer, oral cancer, tonsil cancer, etc. There is a relationship between this type and the development of cervical, rectal, oral and tonsil cancers. The most common disease caused by high-risk HPV infection is cervical cancer, and HPV16 and HPV18 are the two most common oncogenic HPV. Different types of HPV cause different clinical manifestations. It is best to treat HPV virus infection, especially high-risk types, promptly and review them regularly when they are found during physical examination. The HPV vaccine is also effective in reducing the occurrence of HPV by paying attention to hygiene, especially sexual hygiene, fixing sexual partners, strengthening exercise, and enhancing resistance.