The New Crown vaccination for people aged 12-17 years is now in full swing. Parents and adolescents are more concerned about the contraindications to vaccination and whether they can receive the vaccine successfully. While actively responding to the call for vaccination, they should pay attention to whether there are any of the following diseases or allergies that contraindicate vaccination in order to avoid affecting the vaccine effect and their health. History of allergy: 1. People who are allergic to the active ingredients of the vaccine, any of the inactive ingredients, or substances used in the production process, or those who have been allergic to similar vaccines in the past; 2. People who have had serious allergic reactions to vaccines in the past, such as acute allergic reactions, respiratory difficulties, angioneurotic edema, etc. Disease history: 1. Patients with fever or acute diseases, or patients with serious chronic diseases that are in the period of chronic disease attack and not controlled; 2. Patients with epilepsy and other serious neurological diseases, such as Guillain-Barre syndrome, demyelinating diseases, etc.; 3. Patients with malignant tumors undergoing radiotherapy or surgery for less than three years; 4. Immune system diseases (systemic lupus erythematosus, rheumatoid Arthritis, dry syndrome, etc.) The overall principle is to vaccinate with caution. In general, inactivated New Crown vaccine and recombinant subunit vaccine can be administered when the disease is stable. In addition, when vaccinating people aged 12-17 years, they should prepare in advance the identity documents of the vaccinees in accordance with the requirements of the relevant authorities, accompany them throughout the vaccination if requested, and read and fill in the informed consent form carefully. Parents should actively cooperate with the vaccination process and should not have unnecessary worries, as the vaccination will not weaken the child’s immunity, but will enhance the ability to protect against NCC. However, it should be clear that there is still a certain possibility of infection after vaccination, so it is still necessary to wear a mask, avoid places with a lot of traffic, and do a good job of daily protection. Redness and swelling at the injection site, muscle pain, and even hard nodules may occur after vaccination, which are normal and should not cause undue alarm to parents and vaccinators. If a vaccinated person has a high fever that does not go away and other manifestations and complications appear, they should actively contact the doctor at the vaccination site for further consultation and treatment.