Acromegaly: Heart disease, hypertension, dyslipidemia (cholesterol), sleep apnea, joint disease, colon polyps and colon cancer, hypogonadism infertility. Cushing’s disease: heart disease, dyslipidemia, diabetes, hypertension, osteoporosis and fractures, depression, memory loss, muscle weakness, hypogonadism, infertility. Chen Ge, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University: High prolactin is not known to shorten life expectancy; however, lack of normal testosterone production in men can cause osteoporosis and an increased risk of fractures. This also occurs in women with loss of menstrual cycle. Non-secretory adenomas, craniopharyngiomas, Rathke’s cysts, pituitary cysts: There is no known risk of premature death once appropriate hormone replacement has been given. Complications are associated with an adequate amount of hormone replacement.