Nephrotic syndrome (hereinafter referred to as renal syndrome) is a common disease in pediatrics. Glucocorticoid is the drug of choice for this disease. During the application of hormone, children are very prone to complication of infection, and if other immunosuppressive drugs are used at the same time, it is more likely to complicate infection, such as common cold and fever, and infection is one of the important reasons for aggravation or recurrence of renal syndrome. Therefore, the prevention of infection is a very important part of the treatment of renal syndrome. 1, to prevent the formation of some hidden foci of infection. Once the infection foci are formed in some unappreciated diseases, it will also directly affect the conversion of urine protein to negative, or make the kidney disease relapse. Therefore, these hidden dangers should be eliminated early. The oral cavity is the most neglected and at the same time the most likely place to form infections. In addition to maintaining oral hygiene, treating inflammation of oral mucosa, ulcers and gum disease, we should also pay attention to the presence of dental caries when taking care of oral cavity. Statistical data shows that the incidence rate of milk teeth caries in urban children in China is about 80%, and it has the characteristics of many caries, fast development and serious secondary disease. If the caries is not treated in time, the long-term chronic inflammation of the periapical period of the milk teeth can be latent as a focal point of infection, which also directly affects the efficacy of hormone. Children with dental caries should be treated by dentistry in time. In addition, the skin mucosa is the direct channel for bacteria invasion. Besides keeping the skin clean, special attention should be paid to the folds of the skin. If it is a boy, you should pay attention to the prepuce, because if the prepuce is too long, the prepuce will stimulate the skin for a long time, which will lead to inflammation or septic infection and form the foci of infection. If you are a girl, try not to wash your underwear and adult underwear or jacket together to avoid cross-infection. At the same time, parents should pay attention to look after their children, try to avoid all kinds of trauma, children with broken skin, be sure to do a good job of cleaning and disinfection. 2.Keep indoor air clean. On the one hand, we should reduce the movement of people. Children taking hormones are very sensitive to viruses. Especially in the epidemic season of infectious diseases, such as chickenpox, measles and shingles, the symptoms are often very serious. And chickenpox is prohibited hormones, so when there are too many people visiting, should do a good job of persuasion and explanation; try to avoid going to places with large populations to avoid adverse consequences. On the other hand, both to keep the indoor air circulation, but also to pay attention to air disinfection, air is also a vector of infection in children. The amount of bacteria in the air is directly proportional to the chance of infection in the affected child. Indoor cleaning and disinfection should be done. 3, strengthen the warmth and cold work. As the seasons and climate change, parents should promptly add or remove clothing for the child to prevent overheating or cold. In summer, when the air conditioner is on, the temperature difference between indoor and outdoor should not exceed 6 ℃, otherwise the hot and cold imbalance will easily lead to colds and so on. At the same time, anti-mosquito facilities should be prepared. Children taking hormones have low resistance, and the skin is easily broken by bites in summer when there are more mosquitoes. Especially the younger children with delicate skin should pay more attention. Can apply flower lotion or mosquito nets to prevent mosquitoes. 4, pay attention to adjust the diet. Children taking hormones, appetite increased, but the body immune deficiency, so the diet adjustment should not be ignored. Appropriate supplementation of some high-protein, high-calorie diet; supplementation of potassium-rich food, such as bananas; supplementation of calcium-rich vegetables, such as spinach, rape, etc.; attention should also be paid to avoid long-term unreasonable salt avoidance, in order to prevent and correct electrolyte disorders, enhance resistance, and prevent complications. 5, pay attention to psychological care. Psychological factors have a two-way effect, adverse psychological factors can lead to a decline in the body’s immune function, exacerbating the occurrence and development of disease; on the contrary, a good psychological state can prevent and treat the disease. Because of the long duration of the disease, it is easy to relapse after complete remission by treatment, which makes parents have a heavy burden mentally and financially, and children also lose confidence because of the recurrence of the disease, so care and encouragement should be given to the family and children to build confidence, maintain an optimistic and positive attitude, and adhere to treatment. In addition, the combination of Chinese and Western medicine can improve the immune function of the child and reduce the occurrence of infection, thus reducing the recurrence of renal syndrome and improving the efficacy of treatment.