Urticaria with fever is usually infectious urticaria. Patients should consult the doctor for anti-infection and anti-allergy treatment, and the treatment is based on medication. Infectious urticaria refers to those caused by bacterial, fungal, viral or parasitic infections, etc. The main clinical manifestations are fever, clammy, itchy and sore throat. For patients with fever caused by bacterial infection, sensitive antibiotics should be selected according to bacterial culture and drug sensitivity test, and commonly used drugs include amoxicillin and azithromycin. For fever caused by viral infection, antiviral drugs such as acyclovir and oseltamivir can be used as prescribed by the doctor. If the fever is caused by parasitic infection, antifungal drugs such as ketoconazole are commonly given. Patients also need to use drugs such as cetirizine, ebastine, and loratadine, which can relieve symptoms such as windburn and itching. For more serious infectious urticaria, glucocorticoids such as prednisone can be applied in moderation. Patients with urticaria accompanied by fever should consult a doctor in time to clarify the source of infection and actively carry out appropriate treatment to eliminate the cause of the disease and control the symptoms. Meanwhile, after the symptoms are relieved, allergen screening should be conducted as early as possible to avoid re-infection.