The female reproductive organs develop slowly before puberty and are basically in an infantile state. When puberty is reached, in addition to accelerated growth of muscles, bones and internal organs, secondary sexual characteristics and sexual organs also develop rapidly. Estrogen promotes the development of fuller breasts, the development of female reproductive organs, thickening of the labia, lengthening of the vagina, fullness of the uterus, maturation of the ovaries, and growth of body hair. The first menstruation of a woman is called menarche, which is one of the important indicators of the onset of puberty and the beginning of sexual maturity. The sexual axis is unstable at menarche and the menstrual cycle varies in length, with some cycles being very short, around 15 days. Some cycles are very long, several months, or even half a year. The bleeding may be long or short, and the amount of bleeding may be high or low. It takes about 1 to 2 years for some women to have regular menstrual flow. Adolescent dysfunctional uterine bleeding refers to anovulatory uterine bleeding caused by neuroendocrine disorders during adolescence (referred to as gongbao), which occurs in adolescent women within a few years after the first menstruation, and is especially common among female students. The relationship between the hypothalamic-pituitary-ovarian axis is unstable after menarche and is susceptible to changes due to various internal and external environmental influences, such as strenuous activities, mental stress or diseases. The main clinical manifestations are heavy vaginal bleeding, prolonged cycles, incomplete dripping and severe anemia. Prolonged and excessive bleeding, resulting in anemia, dizziness and panic, is called adolescent haemorrhage. Pay attention to adolescent meritorious bleeding because it can not only cause physical damage, such as anemia, infection, lowered body resistance, etc., but also affect study and life in serious cases, and cause great psychological burden, producing anxiety, tension and fear. In the clinic, we often encounter some careless parents and patients who cannot remember their menstrual cycle, and only remember to care after a heavy bleeding or continuous bleeding after several months of not menstruating; there are also painful lessons of anemia and shock due to untimely treatment of adolescent gonorrhea, and the need to scrape the uterus to stop bleeding due to ineffective medication. At present, some parents do not pay attention to adjusting menstruation during puberty, thinking that it is normal for adolescent girls to have irregular menstruation, and that they will get better naturally after a few years, and they even have fear of hormone treatment by doctors, so to speak, and refuse to treat it. Some of them are afraid of missing classes and affecting their studies, which delays the treatment and leads to the deterioration of the condition, seriously affecting the physical and mental development of adolescent girls. The principle of pharmacological treatment for adolescent gynecomastia is to stop bleeding, adjust the cycle and promote the maturation of the hypothalamic-pituitary-ovarian axis, and only use natural estrogen and progesterone to supplement the deficiency of hormone levels in the body, which can establish a normal menstrual cycle and promote the maturation of the hypothalamic-pituitary-ovarian axis. Therefore, we would like to remind that while we care about the nutrition and physical development of adolescent females, we should pay more attention to the abnormal menstruation of adolescent females. After the first menstruation, it is important to record the menstrual condition. Reproductive health during adolescence not only affects physical health during adolescence, but may also affect reproductive function later.