Cleft lip and palate is a disease of congenital malformation of the jaw and face, there are very complex dental and jaw malformations such as fracture of lip and palate tissues, misalignment of various bone segments in the upper jaw, abnormal arch morphology and sympathetic relationship, etc. Internationally, the treatment of cleft lip and palate is sequential, but orthodontic treatment of cleft lip and palate is throughout, thus, the importance of oral orthodontic treatment for cleft lip and palate is evident. From newborn, children with cleft lip and palate have to start orthodontic treatment before surgery, and they also inevitably need orthodontic treatment before and after orthognathic surgery in the mammary row, mixed row, early permanent teeth and adults, because in different periods, children have different growth and development characteristics as well as different dental and jaw malformation performance, so we have correspondingly different treatment goals and methods in orthodontic treatment. Here is a look at the orthodontic treatment for children with cleft lip and palate in different periods. Pre-operative orthodontics for children with cleft lip and palate from 2 weeks to 6 months of age The child needs to wear the PNAM orthodontic appliance from 2 weeks to 1 month of age in order to achieve the best aesthetic results after surgery. The main purpose of the PNAM is to separate the oral and nasal cavities, to lower the tongue to reduce tissue displacement, to complete the sucking and swallowing functions, and to allow the maxillary segment to grow and develop in a favorable direction to reach as normal a physiological position as possible. Nasal bracing promotes nasal cartilage shaping to restore the height of the collapsed nose significantly improving the cosmetic effect. Orthodontic treatment for 6-14 years old 8-10 years old is just before the peak of growth and development, the first permanent molar has been fully erupted, before the peak of growth and development to perform anterior traction orthodontic treatment of complete cleft lip and palate anterior teeth anterior to the underdeveloped maxillary deformity, promote the forward movement of the maxilla, improve the relationship between the upper and lower jaws and the lateral appearance of jaw and facial soft tissue. At the end of the orthodontic treatment, it is the best age for bone implantation, so that the continuity of treatment is better and the orthodontic treatment time is relatively short, and the coordination of teeth, dental arches, syndesmosis, jaws and face is adjusted at the right time to maintain the good oral function and facial appearance of the child. Orthodontic treatment at the age of 18 For those with very serious deformities, orthognathic surgery can be combined with preoperative and postoperative orthodontic treatment when they reach adulthood (18 years old) to achieve both good dental relations and satisfactory facial morphology. From the sequential treatment of children with cleft lip and palate and the means of orthodontic treatment in different periods, we can see that orthodontic treatment plays a pivotal role in the treatment of cleft lip and palate, and it is even more essential for the aesthetic treatment of children with cleft lip and palate. Therefore, children with cleft lip and palate should pay great attention to orthodontic treatment from discovery to treatment, otherwise, it will be difficult to restore the normal appearance and the normal coordination of the dental arch, the fit, the jaw and the face.